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Nonetheless, it is statistically challenging to determine whether the outcome was caused by the pharmacological agent itself, the illness being treated, or a complex interaction between the two

Furthermore, the interplay between ferroptosis and other programmed cell death pathways (e.g., pyroptosis and necroptosis) in driving renal fibrosis is fragmented

The compound has been in pre-clinical investigation for decades

The need for disease-specific biomarkers has been heightened further by calls for biological staging systems in PD 4,5

A unifying feature is their ability to mitigate oxidative stressfor example, many flavonoids, alkaloids, and saponins activate the Nrf2/ARE pathway, upregulating endogenous antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase) to neutralize excess reactive oxygen species (Wang Q